主要从事水产动物疾病与免疫防控研究。重点关注鱼类先天免疫抗菌机制，海水病原微生物侵染宿主的机制，鱼类绿色抗菌肽和疫苗的研发。

[1] Feng JiXing, Liu Ling, Wang HongYe, Zhang Jian*,Li Xuepeng*. A solubleTLR5 is involved in PBLs activation and antibacterial immunity via TLR5MMyD88-signaling pathway in tongue soleCynoglossus semilaevis.Int J BiolMacromol. 230 (2023):123208.(共同通讯作者，中科院一区/IF=8.2)

[2] Chen GuanYu, Feng JiXing, Shi WenKai, Wang HongYe, Zhang Jian,LiXuepeng*, PoClu, a teleost Clusterin, acts as a negative regulator in complementactivation and antibacterial immunity.Aquaculture. 575 (2023): 739791.(通讯作者，中科院一区/IF=4.5)

[3]Li Xuepeng*, Chen Guanyu, Jin Qi, Lou Bangui, Liu Bingjian, Zhang Jian，FengJi-xing，Chen Tian-tian*. CsIL-11, a teleost interleukin-11, is involved inpromoting phagocytosis and antibacterial immune defense.Int J Biol Macromol.192 (2021):1021-1028.(首作+共同通讯作者，中科院一区/IF=6.953)

[4] Chen Guan-yu, Xu Xiao-dong, Feng Ji-xing, Zhang Jian,Li Xue-peng*. A singleC1q A chain promotes leukocytes phagocytosis/chemotaxis and mediates bacterialclearance in Japanese flounderParalichthys olivaceus.Aquaculture. (2024):740840.(通讯作者，中科院一区/IF=3.9)

[5]Li Xuepeng*, Chen Guanyu, Zhang Jian, Li DengLai, Feng Jixing*. A teleostinterleukin-16 is implicated in peripheral blood leukocytes recruitment and antibacterial immunity.Int J Biol Macromol. 187 (2021):821-829.(首作+共同通讯作者，中科院一区/IF=6.953)

[6] Chen Guan-yu, Zhao Kun-yu, Jin Qiu, Zhang Jian,Li Xue-peng*. A novel teleostC1q C chain (PoC1qC) participates in complement and leukocytes antibacterialimmunity.Aquaculture. (2024): 740831.(通讯作者，中科院一区/IF=3.9)

[7]Li Xuepeng*, Sun Jiaqi, Sui Zhihai, Zhang Jian, Feng Jixing. Membraneorthologs of TLR5 of tongue soleCynoglossus semilaevis: Expression patterns,signaling pathway and antibacterial property.Fish Shellfish Immunol. 126(2022):131-140.(首作+通讯作者，中科院二区/IF=4.622)

[8]Li Xuepeng, and Zhang Jian*. Tongue sole (Cynoglossus semilaevis) interleukin10 receptors are involved in the immune response against bacterial infection.DevComp Immunol. 115 (2020): 103885.(首作，中科院三区/ IF=3.192)

[9] Zhao Kun-yu, Huang Hui, Jin Qiu, Wang Lei, Jiao Xu-dong*,Li Xue-peng*,CsIL-20, a tongue sole interleukin-20, negatively mediates leucocyte activity andantibacterial defense.Fish Shellfish Immunol. 145 (2024): 109325.(共同通讯，中科院二区/IF=4.1)

[10]Li Xuepeng, and Zhang Jian*. A live attenuatedEdwardsiella tardavaccineinduces immunological expression pattern in Japanese flounder (Paralichthysolivaceus) in the early phase of immunization.Comp Biochem Phys C. 239 (2020):108872.(首作，中科院三区/ IF=2.892)

[11] Sun JiaQi, Zhao KunYu, Zhang ZiXiang,Li Xuepeng*. Two novel teleostcalreticulins PoCrt-1/2, with bacterial binding and agglutination activity, areinvolved in antibacterial immunity. Fish Shellfish Immunol. 143 (2023): 10920(通讯作者，中科院二区/ IF=4.7)

[12] Zhao KunYu, Fang Yue, Xu RongJing, Zhang Jian, Sun Bin*,Li Xuepeng*.PoIL8-L, a teleost interleukin-8 like, enhances leukocyte cellular vitality and hostdefense against bacterial infections in Japanese flounder (Paralichthys olivaceus).Fish Shellfish Immunol. 153 (2024): 109876.(共同通讯作者，中科院二区/IF=4.1)

[13] Zhao KunYu, Chen Guan-yu, Huang Hui, Jiao XuDong,Li Xuepeng*, ZhangJian*. PoCXCL8, a teleost chemokine, exerts direct bactericidal,chemotactic/phagocytic, and NETs releasing properties, promoting host antibacterial immunity. Fish Shellfish Immunol. 154 (2024): 109874.(共同通讯作者，中科院二区/ IF=4.1)

1.山东省教育厅，山东省高等学校青年创新团队发展计划（2022KJ269），牙鲆正五聚蛋白PTX3抗迟缓爱德华氏菌侵染的机制及应用研究，2023.01-2025.12，在研，主持。

2.国家自然科学基金委员会，青年项目，半滑舌鳎白细胞介素-10抗细菌免疫机制研究（31802329），26万元，2019-01至2021-12，已结题，主持。

3.中国博士后科学基金会，面上项目，半滑舌鳎TLR5信号途径及抗细菌免疫机制研究（2018M632733），2018-05至2020-05，已结题，主持。

4.烟台大学，学科带头人项目启动基金（HX20B36），鱼类白介素抗菌机制研究，2020.06-2025.05，在研，主持。

5.青岛市人力资源和社会保障局，迟缓爱德华氏菌侵染诱导的牙鲆microRNA功能研究，2018.05-2020.05，已结题，主持。

6.国家自然科学基金委员会，联合基金重点支持项目，山东省深远海养殖鱼类病原菌哈维氏弧菌和美人鱼发光杆菌的致病机制（U24A201412），2025-01至2028-01，在研，骨干参与。

7.山东省自然科学基金委员会，面上项目，ZR2020MC198，肿大细胞病毒泛素连接酶ORF64L在病毒感染中的作用机制，2021-01至2023-12，10万元，在研，骨干参与。指导研究生情况：已毕业研究生3人，在读5人，考博1人次，国家奖学金1人次，山东省优秀毕业生1人次，山东省研究生创新成果奖2人次。